The present study was undertaken to investigate the effect of momordica charantia on cognitive functions, total cholesterol levels and cholinesterase che activity in scopolamine induced amnesia in rats. Kshirsagar1 1sudhakarrao naik institute of pharmacy, pusad,m. Effects of nelumbo nucifera rhizome extract on cell. Neuroprotective effects of chlorogenic acid on scopolamine. The therapeutic effect of crocin on scopolamine induced retrograde amnesia in male rats. This article is from iranian journal of pharmaceutical research. We evaluated neuropharmacological properties of yukmijihwangtang yjt against scopolamine injectioninduced memory impairment mice model.
Pdf scopolamineinduced amnesia can be prevented by heat. Khakpai f1, nasehi m, haerirohani a, eidi a, zarrindast mr. Scopolamine induced amnesia has been proposed as a model for dementia where reduced cholinergic function is the suspected cause. Pdf evidence for a direct cholinergic involvement in the. The neurochemistry of memory remains to be determined. Genistein ameliorates scopolamineinduced amnesia in. Brain damage due to oxidative stress can induce impairment in learning and memory abilities. May 14, 2015 hippocampal memory enhancing activity of pine needle extract against scopolamineinduced amnesia in a mouse model. Neuroprotective effects of chlorogenic acid on scopolamine induced amnesia via antiacetylcholinesterase and antioxidative activities in mice. The results were similar to the previously reported cognitive enhancement effects of total soy isoflavones at the dose of 40 mgkg in the scopolamineinduced amnesia model. Research journal of pharmaceutical, biological and chemical sciences, 4 1. Reversal of scopolamineinduced amnesia of passive avoidance by.
Scopolamine did not impair delayed recall of visual or verbal material. Author links open overlay panel nikolaos pitsikas a antonello e rigamonti a silvano g cella a vittorio locatelli a. Qualitative analysis of scopolamineinduced amnesia. Customize your jama network experience by selecting one or more topics from the list below. Gongjindan enhances hippocampal memory in a mouse model of. In this model the scopolamine decreases the central cholinergic neuronal activity, block muscarinic receptor and. In this study, sco 1 mgkg, intraperitoneal injection was used to induce amnesia. Protective role of ashwagandha leaf extract and its.
Pdf ethanol extract and saponin of platycodon grandiflorum. Nanoparticle mediated brain targeted delivery of gallic acid. Antiamnesic activity of vitex negundo in scopolamine. Each animal received session of 15 trials with inter trial duration of 15 s for 5 days. The drug, called scopolamine, also known as the devils breath, is derived from a particular type of tree common in colombia called the borrachero tree. Background scopolamine is a wellknown cholinergic antagonist that causes amnesia in human and animal models. Neuroprotective effects of soy isoflavones on scopolamine.
Scopolamine a cholinergic antagonist may cause amnesia in human and animal models. Mature silkworm powders ameliorated scopolamine induced amnesia by enhancing mitochondrial functions in the brains of mice author links open overlay panel phuong nguyen a 1 keeyoung kim b 1 ayoung kim a c 1 bohey choi a angelina f. Mature silkworm powders ameliorated scopolamine induced amnesia by enhancing mitochondrial functions in the brains of mice. Abdul kalam technical university, lucknow, uttar pradesh. In the present study, the induction of scopolamineinduced amnesia showed suppression of bdnf and trkb expressions in the hippocampus. Cognitive improving effects by highbush blueberry vaccinium. Serum cholesterol and creactive protein crp levels were successfully reduced by lycopene. Taken together, this study strongly showed that gjd exerted antiamnesic actions in a mice model of scopolamineinduced amnesia. Scopolamineinduced amnesia has been proposed as a model for dementia where reduced cholinergic function is the suspected cause. Plant extracts active properties effective on scopolamineinduced. Immunohistochemical markers included ki67, an endogenous marker for active cell cycle, and doublecortin dcx, a marker for. The ameliorating effects of cognitionenhancing chinese. Scopolamine treatment produced strong amnesia in animals tested i and 3 days posttraining but normal retention in animals tested 7 and 10 days after learning.
Scopolamineinduced amnesia in rodent models has been widely used to understand the molecular, biochemical, behavioral changes, and to delineate therapeutic targets of memory impairment. Effects of molsidomine on scopolamineinduced amnesia and hypermotility in the rat. Terminalia chebula extract prevents scopolamineinduced. Taken together, these results demonstrated that soy isoflavones exerted a significant neuroprotective effect on cognitive dysfunctions induced by scopolamine, suggesting that soy isoflavones could be a good candidate for possible treatment of neurodegenerative diseases, such as alzheimers disease ad. Ethanol extract and saponin of platycodon grandiflorum ameliorate scopolamineinduced amnesia in mice. Pdf neuroprotective effects of soy isoflavones on scopolamine. Mature silkworm powders ameliorated scopolamineinduced amnesia by enhancing mitochondrial functions in the brains of mice. The present study examined whether amnesia induced by scopolamine could be counteracted in mice by arecoline, a cholinergic agonist, or by other drugs, epinephrine or glucose, which have been found to enhance memory in aged rodents and humans. Research center, oh, usa according to the manufacturers manual instruction. May 16, 2012 scopolamine induced memory impairment. Memoryenhancing activity of palmatine in mice using elevated. This study of scopolamineinduced memory deficits further defines those cognitive processes which are disrupted. Hippocampal memory enhancing activity of pine needle extract. Strength of scopolamineinduced amnesia as a function of time.
We report seven experiments in young adult mice which examine scopolamines effects on memory retention and whether its amnestic effects are specifically blocked by cholinergic agonists or cholinomimetics. To determine the neuroprotective effect of gin on cognitive dysfunction, scopolamine sco, 1 mgkg, i. Hippocampal memory enhancing activity of pine needle extract against scopolamineinduced amnesia in a mouse model. Anisocoria from scopolamine patches jama jama network.
Experimental evidence for the potential of lycopene in the. Frontiers ethanolic extract of orthosiphon stamineus. Combretaceae is a traditional herbal medicine that is widely used in the treatment of diabetes, immunodeficiency diseases, and stomach ulcer in asia. To study acquision, consolidation and recall stages of memory, aterials and methods. This model can be used to describe the therapeutic targets of memory impairment. We evaluated the neuroprotective effects of chlorogenic acid on learning and memory impairment induced by scopolamine 0. Ginseng berry aqueous extract prevents scopolamine. Antiamnesic activity of vitex negundo in scopolamine induced. Protective effect of nycthanthes arbortristis on scopolamine induced amnesia in rats a behavioural and biochemical approach sonakshi antal, vrish dhwaj ashwlayan and anuj kumar pharmaceutical technology, meerut institute of engineering and technology, meerut, india, dr. Hippocampal memory enhancing activity of pine needle.
Evidence for a direct cholinergic involvement in the scopolamine induced amnesia in monkeys. This study of scopolamine induced memory deficits further defines those cognitive processes which are disrupted. Amnesia of inhibitory avoidance by scopolamine is overcome. Yukmijihwangtang, a traditional korean multiple herbal formulae, improves hippocampal memory on scopolamine injection induced amnesia model of c57bl6 mice hyelim lee, 1 sungah lim, 2 hyewon lee, 3 horyong yoo, 4 and hyeonggeug kim 5. We report seven experiments in young adult mice which examine scopolamine s effects on memory retention and whether its amnestic effects are specifically blocked by cholinergic agonists or cholinomimetics. The main animal model used in cholinergic theory research is the scopolamineinduced memory loss model. Effects of nootropic drugs in a scopolamineinduced amnesia. Amelioration of scopolamineinduced learning and memory. Caffeine improves sperm quality, modulates steroidogenic enzyme activities, restore testosterone levels and prevent oxidative damage in testicular and epididymal tissues of scopolamine.
Zk 93426 did not antagonize the scopolamineinduced impairment of acquisition of the words list. The scoinduced amnesia group exhibited significantly reduced spatial recognition. Scopolamine induced amnesia, while spatial learning and memory was preserved in scopolamine treated fat1 mice. Pdf effects of fructus akebiae on learning and memory. This study was designed to assess the role of caffeine on fertility parameters in testicular and epididymal tissues of. Ras extract 1 gkg significantly prolonged the shortened stepthrough latency induced by scop and cxm, but not pca.
However, there is no report about the effects of ge on scopolamine scopinduced amnesia in mice. Acetylcholine may be one of the neuotransmitters which mediates memory function, since the anticholinergic drug scopolamine produces amnesia in man. The muscarinic cholinergic receptor machr blockade with scopolamine either extended or restricted to the hippocampus, before or after training in inhibitory avoidance ia caused anterograde or retrograde amnesia, respectively, in the rat, because there was no longterm memory ltm expression. Effects of molsidomine on scopolamineinduced amnesia and. The present study was designed to determine whether t. In the present study, we investigated the effect of treadmill exercise on spatial learning ability in relation with cell proliferation in the hippocampus using the scopolamineinduced amnesia mice. Genistein ameliorates scopolamineinduced amnesia in mice. This study examined the effects of nelumbo nucifera rhizome extracts nre on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus dg of a rat model of scopolamine.
We have investigated the neuroprotective and memory enhancing effect of 6gingerol gin, a pungent ingredient of ginger, using an animal model of amnesia. Abstracttwo omega3 fatty acids including docosahexaenoic acid dha and. Dec 15, 2010 chlorogenic acid is a major polyphenolic component of many plants and beverages, and is particularly abundant in coffee. Scopolamine sco is a muscarinic acetylcholine receptor machr antagonist which disturbs learning. Pdf memory enhancing activity of momordica charantia by. In the present study, scopolamine and diazepam significantly impaired memory of mice. Scopolamine hydrobromide supplier cas 114498 tocris. Zk 93426 did not antagonize the scopolamine induced impairment of acquisition of the words list. Scopolamine 3 mgkg ip given before an acquisition trial, reduced the retention of a onetrial passive avoidance step through response in mice.
The present study aimed to evaluate the preventive effects of highbush blueberry vaccinium corymbosum l. Polygalasaponin xxxii, a triterpenoid saponin from. Nanoparticle mediated brain targeted delivery of gallic. S gill, sahil kakkar department of pharmacology, rayat institute of pharmacy. International journal of pharmtech research coden usa. Both drugs on their own and in combination were found to be safe and well tolerated. Pdf in the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. In the present study we investigated the antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. Antiamnesic activity of vitex negundo in scopolamine induced amnesia in rats. Antiamnesic and neuroprotective effects of low dose of. Caine ed, weingartner h, ludlow cl, cudahy ea, wehry s. Fat1 expression enhance hippocampal memory in scopolamine. Similar results were also observed in the prefrontal cortex whereby scopolamine reduced mrnas of bdnf and trkb. Gongjindan enhances hippocampal memory in a mouse model.
Although this has been linked to the decrease in central cholinergic neuronal activity following. View enhanced pdf access article on wiley online library html view download pdf for offline viewing. Retention latencies to enter the dark chamber in the stepthrough passive avoidance test displayed by different groups of rats. A significant antiamnesic effect was also found with nootropic drugs such as piracetam and ucb l059. Caffeine improves sperm quality, modulates steroidogenic.
Memory impairment effect of diazepam has been reported in the literature. The effects if the methanolic extract of radix angelica sinensis umbellifera abbreviated as ras extract and nhexane fraction of ras extract ras h fraction on the various drugsinduced amnesia in rats were studied by using passive avoidance task. Mice were orally administered with yjt 50, 100, or 200 mgkg or tacrine tac, 12. Protective effect of nycthanthes arbortristis on scopolamine induced amnesia in rats a behavioural and biochemical approach sonakshi antal, vrish dhwaj ashwlayan and anuj kumar pharmaceutical technology, meerut institute of. In addition, fat1 expression protected against scopolamine reduced hippocampal neurogenesis and scopolamine induced cell death via bdnf signaling. The effect of fae treatment on a spontaneous alternation behavior tmaze task and b mwm in a scopolamineinduced amnesia model in mice. Naringenin protects against scopolamineinduced dementia in. Download pdf readcube epub xml nlm supplementary material. Scopolamine should be used with extreme caution in geriatric patients since scopolamineinduced mental confusion and other. Radix angelica sinensis extracts ameliorate scopolamine. For the scopolamine model, amnesia was induced in all the groups except the control group by daily intraperitoneal injections of.
When scopolamine is administered as a preoperative medication to patients with pain or severe anxiety, an analgesic andor sedative should be administered concomitantly to avoid scopolamineinduced behavioral changes. Read effects of molsidomine on scopolamineinduced amnesia and hypermotility in the rat, european journal of pharmacology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Neuroprotective effects of chlorogenic acid on scopolamineinduced amnesia via antiacetylcholinesterase and antioxidative activities in mice. The animal model of scopolamine scopinduced amnesia is widely used to study underlying mechanisms and treatment of cognitive impairment. The polygalae radix extract bt11 has been shown to have memoryenhancing effects in rats with scopolamineinduced amnesia 12 and cognitionimproving effects in. The underlying mechanisms involve the regulation of the hippocampal cholinergic system and neurogenesis via activation of bdnf. Ethanol extract and saponin of platycodon grandiflorum.
Effects of nootropic drugs in a scopolamineinduced. Scopolamine induced amnesia can be prevented by heat shock pretreatment in rats. Yukmijihwangtang, a traditional korean multiple herbal. Cr and psoralea corylifolia pcon the scopolamine scop. A single administration of cholinergic agonists such as oxotremorine, bm5, or arecoline, antagonized this amnesic effect of scopolamine. Osabutey a d young han park e hyuntai lee f sang deok ji b young ho koh a d. Terminalia chebula extract prevents scopolamineinduced amnesia.
Wistar rats 180200 g were trained on active avoidance task. The study was to investigate the ameliorating effects of three chinese herbs achyranthes bidentata ab, ophiopogon japonicus oj and cnidium monnieri cm on scopolamine scop and mk801induced amnesia by using a passive avoidance task in rats. Icr mice were orally administered donepezil 5 mgkg, blueberry extract 120 mgkg, and bv 120 mgkg for 7 days. Morris water maze, hebbwilliams maze and elevated plus maze served as exteroceptive memory models, whereas scopolamine scoinduced amnesia and alprazolam alp. View and buy high purity scopolamine hydrobromide from tocris bioscience. For the induction of amnesia, 1 mgkg scopolamine hydrobromide was administered intraperitoneally once a. Of ten chinese herbs, only pg, png, ge and cc prolonged the scop. Amnesia induced by scopolamine has been widely used to understand the biochemical and behavioral changes in rodents. A visual presentation of pictures and a verbal words list memory test were applied. Read qualitative analysis of scopolamineinduced amnesia, psychopharmacology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at. May 14, 2015 hippocampal memory enhancing activity of pine needle extract against scopolamineinduced amnesia in a mouse model jinseok lee, 1 hyeonggeug kim, 1 hyewon lee, 2 jongmin han, 1 samkeun lee, 3 dongwoon kim, 4 arthanari saravanakumar, 1 and changgue son a, 1. Both the expg groups and the sap group exhibited significant amelioration of scopolamineinduced amnesia as measured in both the passive avoidance task and the morris water maze task. Pdf effect of aqueous piper betle leaf extract against. A possible mechanism for this interaction involving the septohippocampal cholinergic pathway is discussed.
Neuroprotective effect and molecular mechanism of 6. Effect of rosuvastatin on learning and memory in scopolamine. Deb, debasree and nayak, veena and bairy, kl and rao, mohandas kg and shetty, jeevan and hegde, mangala v and koshy, salini s 20 antiamnesic and neuroprotective effects of low dose of ramipril and losartan in scopolamineinduced amnesia model of dementia. Furthermore, scopolamine induced an increase in brain acetylcholinesterase and oxidative stress, responsible for amnesia, was significantly reduced by both the doses of lycopene. Treatment with molsidomine failed to reverse scopolamine induced amnesia in this test. Morris water maze, hebbwilliams maze and elevated plus maze served as exteroceptive memory models, whereas scopolamine sco induced amnesia and alprazolam alp. The animal model of scopolamine scopinduced amnesia is widely used to study underlying mechanisms and treatment of cognitive impairment in neurodegenerative diseases. The therapeutic effect of crocin on scopolamine induced. Effects of concurrent administration of physostigmine and methylphenidate with scopolamine.
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